- Women with COPD are far more likely than men to be never smokers, have worse bronchiectasis, and have severe symptoms but less obstruction on pulmonary lung function tests.
- Results are from the Korea COPD Subgroup Study (KOCOSS).
Why this matters
- Findings could raise awareness among primary care clinicians of sex-based features of COPD, beyond generalized risk factors.
- Multicenter cohort study (N=2515) of patients with COPD aged >40 years with postbronchodilator FEV1/FVC ≤70% of normal predicted value.
- Funding: Research of Korea CDC.
- Compared with men, women were:
- More likely to be never smokers (60.5% vs 3.7%; P<.01>
- Less likely to be current smokers (12.6% vs 28.0%; P<.01>
- More likely to have a history of bronchiectasis (12% vs 7.2%; P=.02).
- More likely to have had respiratory infection in childhood (32.7% vs 18.5%; P<.01>
- More likely to have a history of asthma (44.1% vs 31.2%; P<.01>
- Postbronchodilator FEV1% predicted (66.2% vs 61.6%; P<.01>
- FEV1/FVC (55.9% vs 50.8%; P<.01>
- Residual volume/total lung capacity (47.0% vs 43.8%; P=.02).
- Cross-sectional, observational.
- Generalizability unclear.