- Osteopenia/osteoporosis, hypogonadism, and primary hypothyroidism are the most common endocrine complications in patients with beta-thalassemia intermedia (β-TI).
Why this matters
- Data on the prevalence and type of endocrine disorders are limited in this patient group.
- The most prevalent complications were osteopenia/osteoporosis (26.2%), hypogonadism (9.8%), and primary hypothyroidism (5.2%).
- Age >35 years was associated with osteoporosis (OR, 7.870; P<.001 hypogonadism and noninsulin-dependent diabetes mellitus>
- Splenectomy was associated with osteoporosis (OR, 1.736; P=.045).
- Hydroxyurea was associated with reduced risk for noninsulin-dependent diabetes mellitus (OR, 0.259; P=.034).
- 522 patients with β-TI were analyzed for endocrine disorders and associated risk factors.
- Funding: None disclosed.
- A cross-sectional study with a heterogeneous patient population.