What are the top 3 endocrine complications in beta-thalassemia intermedia?

  • Karimi M & al.
  • Endocrine
  • 18/12/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Osteopenia/osteoporosis, hypogonadism, and primary hypothyroidism are the most common endocrine complications in patients with beta-thalassemia intermedia (β-TI).

Why this matters

  • Data on the prevalence and type of endocrine disorders are limited in this patient group.

Key results

  • The most prevalent complications were osteopenia/osteoporosis (26.2%), hypogonadism (9.8%), and primary hypothyroidism (5.2%).
  • Age >35 years was associated with osteoporosis (OR, 7.870; P<.001 hypogonadism and noninsulin-dependent diabetes mellitus>
  • Splenectomy was associated with osteoporosis (OR, 1.736; P=.045).
  • Hydroxyurea was associated with reduced risk for noninsulin-dependent diabetes mellitus (OR, 0.259; P=.034).

Study design

  • 522 patients with β-TI were analyzed for endocrine disorders and associated risk factors.
  • Funding: None disclosed.

Limitations

  • A cross-sectional study with a heterogeneous patient population.