- Type 2 diabetes (T2D) is associated with pulmonary function impairment, independent of sex, smoking status, or worldwide location.
Why this matters
- Pulmonary function test (PFT) impairment has not been well-studied in people with T2D.
- A meta-analysis including 66 studies of 11,134 individuals with T2D and 48,377 control participants without T2D.
- Funding: None.
- Pooled mean differences were as follows:
- Predicted percentage of FEV1 (41 studies): −7.15 (P<.0001>
- Predicted percentage of FVC (35 studies): −9.21 (P<.0001>
- FEV1/FVC ratio (45 studies): −0.27 (P<.69>
- Forced expiratory flow at 25%-75% of total lung capacity (13 studies): −9.89 (P<.0001>
- Predicted percentage of peak expiratory flow (15 studies): −9.79 (P<.0001>
- Discrepancies in study selection and quality assessment resolved by consensus.
- Heterogeneity between studies.
- Only half of the studies included ≥50 with T2D.
- Most studies did not report results by sex.