Systematic review: topical cantharidin a good choice for wart clearance

  • Vakharia PP & al.
  • Am J Clin Dermatol
  • 10/08/2018

  • Brian Richardson, PhD
  • Clinical Essentials
L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano

Takeaway

  • A systematic review suggests that topical cantharidin yields significant clearance of warts and variable clearance for molluscum contagiosum.

Why this matters

  • Data lend support to routine use of topical cantharidin for warts, particularly in combination with podophyllotoxin and salicylic acid.

Key results

  • Topical cantharidin was associated with clearance rates ranging between 15.4% and 100% for molluscum contagiosum.
  • Topical cantharidin monotherapy was associated with clearance rates ranging between 64% and 90.8%.
  • Topical cantharidin was associated with clearance rates ranging between 81% and 100% for plantar warts when combined with podophyllotoxin and salicylic acid.
  • The most common adverse events were pain (7%-85.7%), blistering (10%-100%), and hyper/hypopigmentation (1.8%-53.3%).

Study design

  • 20 studies assessing topical cantharidin treatment of molluscum contagiosum or warts were reviewed (1752 patients overall).
  • Funding: Agency for Healthcare Research and Quality; Dermatology Foundation.

Limitations

  • Overall low level of evidence.