- Current treatments most commonly used to treat status migrainosus are largely ineffective, with only 22% of patients being pain free at 48 hours after treatment.
Why this matters
- Status migrainosus, a condition characterized by migraines that last longer than 3 days even with treatment, is widely understudied.
- Study of patients with episodic and chronic migraine who experienced continuous and prolonged attacks for >72 hours and who were treated with dexamethasone, ketorolac, lidocaine 2%, or naratriptan.
- Outcome: response rate after 24 hours of treatment.
- Funding: Migraine Research Foundation.
- Overall response rate of rendering patients pain-free within 24 hours and maintaining the pain-free status for 48 hours was 22%.
- Treatment success rates for achieving pain-free status within 24 hours were higher for dexamethasone (30.8%) and nerve blocks (24.1%) compared with ketorolac (11.1%) and naratriptan (11.1%).
- Proportion of patients achieving a pain-free status increased with time (at 2, 12, 24, 48, 72, and 96 hours it increased gradually from 2% to 8% to 23% to 37% to 43% to 53%).
- Observational study.
- Small sample size.