- Statins are associated with less severe hypoglycemia (SH) in patients with diabetes who are over age 65 years.
- The effect does not appear to be explained by poorer glycemic control or class of glucose-lowering agent used.
Why this matters
- Statins raise blood glucose levels and increase risk for type 2 diabetes, but the reverse protective consequence of protection against severe hypoglycemia had not been previously studied.
- Single-center study of 389 patients age >65 years with diabetes, of whom 8.5% (33) had experienced ≥1 severe hypoglycemic episode (with severe cognitive impairment requiring assistance from another person) during the past 6 months.
- Funding: Institutional grant ANR-DGOS; nonprofit patient association ASSERADT.
- In multivariate analysis, statin treatment was associated with lower SH risk:
- OR, 0.34 (P=.01).
- Insulin treatment (in 43.4%) was linked to higher SH risk:
- OR, 3.57 (P=.02).
- HbA1c was similar in the SH vs no SH groups.
- Small sample size.
- Hypoglycemia self-reported.
- Single (French) center.