- Postmenopausal women with severe vitamin D deficiency or a lack of vitamin D supplementation had a significantly increased risk of lumbar disc degeneration (LDD) and lower back pain (LBP) in this observational study.
Why this matters
- Hypovitaminosis D is common in postmenopausal women.
- Serum vitamin D concentration
- Study of 232 postmenopausal women (mean age, 65.6±10.1 [45-90] years) collected during 2017-2018.
- Funding: National Natural Science Foundation of China; others.
- 12.9% had severe deficiency, 74.6% had deficiency/insufficiency, and 12.5% had normal levels of vitamin D.
- Patients in severe deficiency group vs those in other groups had:
- Higher visual analog scale scores for LBP (P=.002) and bone mineral density (P=.004).
- Severe LDD in the lumbosacral region (L4/5, L5/S1; P<.05>
- An inverse correlation was observed between vitamin D level and severity of disc degeneration (L2/3, L4/5, L5/S1; P>.05).
- High incidence of moderate-to-severe pain was associated with:
- Smoking (P=.035).
- Severe vitamin D deficiency (P=.008).
- Lack of vitamin D supplementation (P=.009).
- Vitamin D deficiency (P=.032).
- Osteoporosis (P=.007).
- Retrospective study design.
- Small number of participants.