- At least 19% of new-onset type 2 diabetes (T2D) patients with hypertension had primary aldosteronism (PA) in this study.
Why this matters
- Few studies have addressed this comorbidity.
- Total 256 Chinese outpatients with new-onset T2D and hypertension were screened for PA.
- Patients with aldosterone renin activity ratio (ARR) ≥30 ng/dL/ng/mL/hour and plasma aldosterone concentration (PAC) ≥15 ng/dL underwent confirmatory captopril challenge test (CCT) for PA, with PA diagnostic criteria:
- After CCT, (1) PAC decreased
- 3 groups defined: screening test negative, screening test positive/CCT negative, and PA diagnosed.
- Funding: Hunan Provincial Science and Technology Department.
- Positive screening test in 39%, PA diagnosed in 19%.
- Compared with screening-negative and screening-positive/CCT-negative groups:
- More PA-diagnosed patients had systolic BP ≥160 mmHg (71% vs 15% and 16%, respectively; P<.001>
- Fewer had hypertension family history (31% vs 69% and 70%; P<.001>
- Serum potassium was lower (P<.001 respectively>
- Higher PAC (P<.001>
- Higher ARR (P<.001 and>
- Lower plasma renin activity (P<.001>
- Small sample.
- Single center.