Preterm labor: a new biomarker panel aids prediction in asymptomatic women

  • Am J Obstet Gynecol MFM

  • Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano

Takeaway

  • A novel multibiomarker vaginal swab assay shows promise in predicting preterm birth in asymptomatic women.

Why this matters

  • Preterm birth is a major contributor to perinatal morbidity and mortality worldwide.
  • A multibiomarker test may replace current tests like the fetal fibronectin test.

Key results

  • 7 biomarkers (PEDF, GGH, LAMC2, ECM1, IL-1RA, VDBP, and TIMP-1) that were predictive of preterm birth identified.
  • Testing in the validation cohort demonstrated a sensitivity of 91% (95% CI, 62%-100%) and specificity of 78% (95% CI, 70%-84%).

Study design

  • Prospective observational cohort study, the Predicting PreTerm Labour (PPeTaL) study.
  • Asymptomatic pregnant women between 16 weeks 0 days and 24 weeks 0 days were recruited (n=301).
  • Cervicovaginal fluid samples collected and stored at time of admission to study (n=286).
  • A training cohort (n=136) was followed by a validation cohort (n=150).
  • Bioinformatics analysis used to detect biomarkers.
  • Funding: Carmentix; University of Melbourne; Royal Women’s Hospital; Mercy Hospital for Women.

Limitations

  • Small numbers in study.
  • Test needs validation.