- A novel multibiomarker vaginal swab assay shows promise in predicting preterm birth in asymptomatic women.
Why this matters
- Preterm birth is a major contributor to perinatal morbidity and mortality worldwide.
- A multibiomarker test may replace current tests like the fetal fibronectin test.
- 7 biomarkers (PEDF, GGH, LAMC2, ECM1, IL-1RA, VDBP, and TIMP-1) that were predictive of preterm birth identified.
- Testing in the validation cohort demonstrated a sensitivity of 91% (95% CI, 62%-100%) and specificity of 78% (95% CI, 70%-84%).
- Prospective observational cohort study, the Predicting PreTerm Labour (PPeTaL) study.
- Asymptomatic pregnant women between 16 weeks 0 days and 24 weeks 0 days were recruited (n=301).
- Cervicovaginal fluid samples collected and stored at time of admission to study (n=286).
- A training cohort (n=136) was followed by a validation cohort (n=150).
- Bioinformatics analysis used to detect biomarkers.
- Funding: Carmentix; University of Melbourne; Royal Women’s Hospital; Mercy Hospital for Women.
- Small numbers in study.
- Test needs validation.