- Hormone therapy (HT) in the menopausal period does not significantly improve muscle mass.
Why this matters
- Muscle loss has been associated with menopause and declining estrogen levels.
- Decline in age-related muscle mass is associated with increased risk for disability, functional impairments, longer hospital stays, and increased risk for mortality.
- HT was not significantly associated with improved muscle mass compared with unexposed participants: HT users lost 0.06 kg less lean body mass vs unexposed controls (P=.26).
- Systematic review and meta-analysis (12 randomized clinical trials, n=4474 in meta-analysis).
- Studies were included if postmenopausal women received HT and lean body mass or fat-free mass was measured as an outcome.
- Primary study outcome was the overall absolute change in lean body mass.
- Funding: None disclosed.
- Limitations related to limitations of original studies.