- Recreational physical activity is associated with improved survival in patients diagnosed with endometrial cancer.
- Prediagnosis activity prolongs DFS; postdiagnosis activity improves both DFS and OS.
Why this matters
- Clinicians should recommend physical activity to newly diagnosed patients and survivors to improve health-related QoL and survival.
- 425 women who were diagnosed with invasive endometrial cancer during 2002-2006 and followed until 2019.
- Funding: Canadian Institutes of Health Research; others.
- The median follow-up was 14.5 years.
- Higher prediagnosis recreational physical activity (>14 vs ≤8 metabolic equivalent task [MET]-hours/week/year) significantly improved DFS (HR, 0.54; Ptrend=.04) but not OS (HR, 0.56; Ptrend=.06).
- Higher postdiagnosis recreational physical activity (>13 vs ≤5 MET-hours/week/year) was associated with improved:
- DFS (HR, 0.33; Ptrend=.001).
- OS (HR, 0.33; Ptrend=.007).
- Participants who maintained high recreational physical activity levels from pre- to postdiagnosis vs those who maintained low physical activity showed improved:
- DFS (HR, 0.35; 95% CI, 0.18-0.69).
- OS (HR, 0.43; 95% CI, 0.20-0.94).