Physical activity tied to improved survival in endometrial cancer

  • Friedenreich CM & al.
  • J Clin Oncol
  • 07/10/2020

  • Deepa Koli
  • Univadis Clinical Summaries
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Takeaway

  • Recreational physical activity is associated with improved survival in patients diagnosed with endometrial cancer.
  • Prediagnosis activity prolongs DFS; postdiagnosis activity improves both DFS and OS.

Why this matters

  • Clinicians should recommend physical activity to newly diagnosed patients and survivors to improve health-related QoL and survival.

Study design

  • 425 women who were diagnosed with invasive endometrial cancer during 2002-2006 and followed until 2019.
  • Funding: Canadian Institutes of Health Research; others.

Key results

  • The median follow-up was 14.5 years.
  • Higher prediagnosis recreational physical activity (>14 vs ≤8 metabolic equivalent task [MET]-hours/week/year) significantly improved DFS (HR, 0.54; Ptrend=.04) but not OS (HR, 0.56; Ptrend=.06).
  • Higher postdiagnosis recreational physical activity (>13 vs ≤5 MET-hours/week/year) was associated with improved:
    • DFS (HR, 0.33; Ptrend=.001).
    • OS (HR, 0.33; Ptrend=.007).
  • Participants who maintained high recreational physical activity levels from pre- to postdiagnosis vs those who maintained low physical activity showed improved:
    • DFS (HR, 0.35; 95% CI, 0.18-0.69).
    • OS (HR, 0.43; 95% CI, 0.20-0.94).

Limitations

  • Observational.