- An increase in the ratio of 2 pepsinogen (PG) isozymes measured in serum (PG I divided by PG II) confirms Helicobacter pylori infection eradication with high validity.
- Performance is comparable to urea breath test and stool antigen test.
Why this matters
- H pylori infection leads to lower PG I/II ratio.
- Confirming H pylori eradication using an increased ratio would be convenient and cost-effective.
After treatment, in the eradication success group (n=433) vs the failure group (n=129):
—PG I: 33.6 vs 54.2 ng/dL (P<.05> —PG II: 7.5 vs 23.3 ng/dL (P<.05 and> —PG I/II ratio: 4.5 vs 2.5 (P<.05>
- Percentage change in PG I/II ratios posttreatment compared with pretreatment in the success group vs the failure group: 108.2 vs 6.8 (P<.05>
- Using those values as cutoffs, sensitivity and specificity for H pylori detection were 93.1% and 93.8%, respectively.
- Retrospective study of 562 patients undergoing eradication of H pylori infection.
- Serum PG I/II ratio was measured and compared before and after treatment.
- Gold-standard urea breath test was performed 3 mo after treatment.
- Outcomes were percentage changes in serum PG I/II ratios before and 3 mo after treatment.
- Funding: None.
- Small retrospective study.
- Optimum cutoffs unclear.