PCOS linked to increased VTE risk

  • Gariani K & al.
  • Thromb Res
  • 20/11/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • PCOS is associated with increased risk of venous thromboembolism (VTE), according to a systematic review and meta-analysis.

Why this matters

  • Few studies have examined the potential association between PCOS and VTE risk, necessitating this meta-analysis.

Key results

  • Patients with PCOS had increased risk of VTE in unadjusted analysis (5 studies; OR, 1.70; 95% CI, 1.42-2.04) and in analysis adjusted for obesity and hormonal treatment (3 studies; OR, 1.89; 95% CI, 1.60-2.24).

Study design

  • 5 studies were included in the meta-analysis.
  • Funding: None.

Limitations

  • Potential misclassification bias due to use of administrative codes.
  • Only 5 included studies.
  • Heterogeneity between included studies.