Patients with psoriasis face slightly increased risk for Alzheimer disease

  • Kim M & al.
  • Sci Rep
  • 15/04/2020

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Psoriasis is associated with a slightly increased incidence of Alzheimer disease (AD), according to a national database review.

Why this matters

  • This correlation suggests that increased screening for AD in patients with psoriasis may be justified.

Key results

  • 2.11% of patients with psoriasis and 1.87% of control participants were diagnosed with AD.
  • Psoriasis was associated with a slightly increased risk for AD:
    • HR, 1.09 (P<.0001>
  • In subgroup analysis, risk for AD was increased in those who were not receiving systemic therapy vs those who were:
    • HR, 1.098 (95% CI, 1.075-1.121) without systemic therapy.
    • HR, 0.988 (95% CI, 0.896-1.086) with systemic therapy.

Study design

  • Data for 535,927 patients with psoriasis and 2,679,635 age- and sex-matched control individuals from the Korean National Health Insurance System database were analyzed for incident AD.
  • Funding: Institute of Clinical Medicine Research in the Yeouido St. Mary’s Hospital, Catholic University of Korea.

Limitations

  • Observational study of large database.
  • No causation established.