- Psoriasis is associated with a slightly increased incidence of Alzheimer disease (AD), according to a national database review.
Why this matters
- This correlation suggests that increased screening for AD in patients with psoriasis may be justified.
- 2.11% of patients with psoriasis and 1.87% of control participants were diagnosed with AD.
- Psoriasis was associated with a slightly increased risk for AD:
- HR, 1.09 (P<.0001>
- In subgroup analysis, risk for AD was increased in those who were not receiving systemic therapy vs those who were:
- HR, 1.098 (95% CI, 1.075-1.121) without systemic therapy.
- HR, 0.988 (95% CI, 0.896-1.086) with systemic therapy.
- Data for 535,927 patients with psoriasis and 2,679,635 age- and sex-matched control individuals from the Korean National Health Insurance System database were analyzed for incident AD.
- Funding: Institute of Clinical Medicine Research in the Yeouido St. Mary’s Hospital, Catholic University of Korea.
- Observational study of large database.
- No causation established.