Given several years, atrophic gastritis (AG) or intestinal metaplasia (IM) in patients with Helicobacter pylori (HP) can resolve completely after eradication of the organism.
Why this matters
Why HP eradication reduces risk for gastric cancer (GC) is unclear, as is whether AG or IM can regress after eradication.
- Prospective case-control study of 1649 Korean adults who either had gastrointestinal symptoms or were undergoing GC surveillance.
- To evaluate for AG and IM, esophagogastroduodenoscopy and biopsies were performed at baseline (n=1649) and for 1-10 years afterward (n=948).
- HP-positive participants underwent eradication therapy.
- HP-negative, HP-eradicated, and HP-noneradicated patients compared with regard to AG and IM regression.
- Funding: South Korean government.
- Excluding 350 participants with gastric dysplasia or GC on follow-up, 598 were analyzed.
- AG improved vs baseline in HP-eradicated group (P<.001 all points>
- Significant baseline differences vs the HP-negative group disappeared after >1 year of follow-up; and
- No significant changes seen vs baseline in HP-negative or HP-noneradicated groups.
Many participants lost to follow-up.