OSA is linked to increased risk for non-Hodgkin lymphoma

  • Choi JH & al.
  • Leuk Res
  • 15/09/2020

  • Miriam Davis, PhD
  • Clinical Essentials
L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano

Takeaway

  • Obstructive sleep apnea (OSA) is associated with an increased incidence of non-Hodgkin lymphoma (NHL).
  • Results are based on data from the Korean National Health Insurance Service covering more than 2 million people.

Why this matters

  • OSA may be a modifiable risk factor for NHL.

Study design

  • Retrospective cohort study comparing all patients aged ≥20 years who made an OSA-related claim (n=198,574), propensity age- and sex-matched with those who did not (n=992,870), during the same period (2007-2014).
  • Patients and control participants were followed for the incidence of NHL.
  • Funding: None disclosed.

Key results

  • Follow-up was 4.8±2.3 years.
  • The incidence of NHL was increased by 40% in patients with OSA vs control participants (HR, 1.40; 95% CI, 1.16-1.69).
  • The HR was somewhat higher for women (1.62; 95% CI, 1.07-2.38) vs men (1.28; 95% CI, 1.03-1.59).
  • The groups did not differ regarding age.

Limitations

  • Retrospective, observational.