- Obstructive sleep apnea (OSA) is associated with a 2-fold increased risk for depression, according to a meta-analysis.
Why this matters
- Screening for depression may be warranted in patients with OSA.
- Meta-analysis of 11 articles published between 2010 and 2019 after a multidatabase search.
- Separate meta-analyses were conducted for cross-sectional (n=6) and longitudinal studies (n=5).
- Funding: None.
- No association between OSA and depression in data from cross-sectional studies:
- OR, 1.12 (95% CI, 0.78-1.47).
- OSA was associated with more than twice the risk for depression in data from the longitudinal studies:
- Risk ratio, 2.18 (95% CI, 1.47-2.88).
- Longitudinal studies showed high heterogeneity (I2=72.8%).
- Small number of studies.
- Observational design of both cross-sectional and longitudinal studies.