OSA is linked to heightened risk for depression: meta-analysis

  • Edwards C & al.
  • Maturitas
  • 01/12/2020

  • Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • Obstructive sleep apnea (OSA) is associated with a 2-fold increased risk for depression, according to a meta-analysis.

Why this matters

  • Screening for depression may be warranted in patients with OSA.

Study design

  • Meta-analysis of 11 articles published between 2010 and 2019 after a multidatabase search.
  • Separate meta-analyses were conducted for cross-sectional (n=6) and longitudinal studies (n=5).
  • Funding: None.

Key results

  • No association between OSA and depression in data from cross-sectional studies:
    • OR, 1.12 (95% CI, 0.78-1.47).
  • OSA was associated with more than twice the risk for depression in data from the longitudinal studies:
    • Risk ratio, 2.18 (95% CI, 1.47-2.88).

Limitations

  • Longitudinal studies showed high heterogeneity (I2=72.8%).
  • Small number of studies.
  • Observational design of both cross-sectional and longitudinal studies.