- One-quarter of patients with chronic kidney disease (CKD) receive proton pump inhibitors (PPIs) without having a US Food and Drug Administration (FDA)-approved indication.
Why this matters
- PPIs increase the risk of acute kidney injury, development of CKD, and progression to end-stage renal disease.
- Reduction in unnecessary use in patients with CKD has the potential to improve health and reduce costs.
- Retrospective chart review in a Veterans Affairs outpatient nephrology clinic.
- Patients were included who had an estimated glomerular filtration rate of 2.
- Patients were characterized as having or not having an approved indication for use of PPIs, based on FDA and American College of Gastroenterology guidelines.
- Of 91 patients with CKD, 22 had a PPI indication, of whom 13 were using a PPI.
- Of the 69 patients without an indication, 24 (35%, or 26% of the total population) were using a PPI.
- There was no difference in the duration of use for patients with vs without an indication (331 vs 319 days, P=.80).
- Single-center, retrospective study.