Migraine prevalence higher in patients with endometriosis

  • Maitrot-Mantelet L & al.
  • Cephalalgia
  • 06/12/2019

  • Kelli Whitlock Burton
  • Clinical Essentials
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Takeaway

  • Migraine prevalence was significantly higher in patients with endometriosis than in those without endometriosis.
  • The prevalence was higher in those with ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) phenotypes, but not superficial peritoneal (SUP) endometriosis, and was highest in patients with endometrioma, regardless of phenotype.

Why this matters

  • Women of reproductive age with a history of migraines should be screened for endometriosis.

Study design

  • This case-control study used data from 314 nonpregnant women (age,
  • Funding: None.

Key results

  • 58% (n=182) of women had histologically proven endometriosis; 42% (n=132) of women had no visual endometriosis.
  • Migraine headache was more frequent in women with endometriosis than in those without (35.2% vs 17.4%; P=.003).
  • Risk for endometriosis phenotypes associated with migraine:
    • SUP: OR, 1.97 (95% CI, 0.88-4.40).
    • OMA: OR, 2.78 (95% CI, 1.11-6.98).
    • DIE: OR, 2.51 (95% CI, 1.25-5.07).
  • The most significant risk occurred in endometrioma regardless of endometriosis phenotype (OR, 3.23; 95% CI, 1.53-6.84).
  • The visual analogue score for chronic noncyclic pelvic pain was higher in women with migraine compared with in women without headache (3.6±2.9 vs 2.3±2.8; P=.007).

Limitations

  • Possibility of selection bias.

Coauthored with Chitra Ravi, MPharm