- Psoriasis is associated with increased risk for several cancer types, according to a systematic review and meta-analysis.
Why this matters
- This meta-analysis supports a previously reported link between psoriasis and cancer risk while clarifying the contributions of psoriatic arthritis and biologic therapies.
- Patients with psoriasis had overall cancer prevalence of 4.78%.
- Risk ratio (RR), 1.21 (95% CI, 1.11-1.33).
- Risk (RR; 95% CI) was increased for:
- Keratinocyte cancer: 2.28 (1.73-3.01).
- Lymphomas: 1.56 (1.37-1.78).
- Lung cancer: 1.26 (1.13-1.40).
- Bladder cancer: 1.12 (1.04-1.19).
- Cancer risk was not increased in patients with psoriasis treated with biologic agents (RR, 0.97; 95% CI, 0.85-1.10) or with psoriatic arthritis (RR, 1.02; 95% CI, 0.97-1.08).
- 112 studies with 2,053,932 total patients were included in the meta-analysis.
- Funding: None disclosed.
- Heterogeneity between included studies.