Meta-analysis: bacterial infection implicated in 50% of COPD exacerbations

  • Moghoofei M & al.
  • Infection
  • 03/09/2019

  • Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • A meta-analysis finds that bacterial infections are implicated in 49.59% of acute COPD exacerbations.

Why this matters

  • This is the first meta-analysis to identify the prevalence of bacterial infections in acute exacerbations.

Study design

  • Meta-analysis of 118 studies (n=19,409 patients) after search of PubMed, ISI Web of Science, and Scopus.
  • Funding: None disclosed.

Key results

  • Bacterial infections have a prevalence of 49.59% (95% CI, 44.18%-55%) in acute COPD exacerbations, with high heterogeneity, I2=98.23%.
  • The most prevalent bacteria were Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus.

Limitations

  • High heterogeneity.
  • No examination of viral infections.