Many patients with epilepsy meet criteria for major depressive disorder | AES


  • RSi Communications
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Takeaway

  • As many as 3 out of 10 patients with epilepsy meet formal criteria for major depressive disorder.

Why this matters

  • Little is known about rates of depression in older adults with epilepsy.

Study design

  • Researchers at Rush University in Chicago retrieved the electronic medical record of all patients seen at the Rush Epilepsy Clinic in 2014-2016.
  • Patients ≥60 years with a confirmed diagnosis of epilepsy were included.

Key results

  • 73 patients (48 female) have been identified; the mean age was 66.
  • The average duration of epilepsy was 17 years; median seizure frequency was 1 year.
  • The majority were on a single antiepileptic drug (AED), 9 required three AEDs, and 14 required 2.
  • The average score on the NDDI-E was 11+/- 4 (>10 is diagnostic for depression) and on the PHQ-GAD-7 was 5 +/- 5 (>15 is diagnostic for anxiety).
  • 52% (n=38) scored positive for depression, while only 5% (n=4) scored positive for anxiety.
  • Approximately 17%-30% of patients will meet formal criteria for major depressive disorder and 21% of patients with poorly controlled temporal lobe epilepsy will have major anxiety disorder.