- Later-onset type 1 diabetes (T1D) is an independent and significant risk factor for developing additional autoimmune conditions (AICs).
- People with adult-onset T1D, especially women, should be monitored for other AICs.
Why this matters
- Additional AICs associated with T1D may have serious health consequences.
- Records analyzed for 1212 adults with T1D (age, 19-96 years), including 35.1% with ≥1 AIC.
- Funding: Washington University Diabetes Research Center; NIH; and other non-industry grants.
- Presence of other AICs increased with age, from 19.8% in those ≤29 years to 47.4% for >60 years.
- Mean current ages for those without vs with additional AICs were 44.3 vs 51.3 years, respectively (P<.0001>
- aOR for additional AICs for age ≥60 vs ≤29 years was 3.70 (P<.0001>
- Additional AICs were more common in women vs men (OR, 2.75; P<.0001 and in those with t1d onset vs years>
- The most common additional AICs were hypothyroidism (22.0%), autoimmune collagen vascular disease (6.5%), hyperthyroidism (5.0%), skin/hair disorders (4.5%), and pernicious anemia (4.5%).
- Single, tertiary referral center study.
- Lack of standardized screening.
- No mortality data or genetic testing.