Later-onset T1D bumps risk for additional autoimmune conditions

  • Hughes JW & al.
  • Diabetes Care
  • 25/10/2018

  • Miriam Tucker
  • Clinical Essentials
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Takeaway

  • Later-onset type 1 diabetes (T1D) is an independent and significant risk factor for developing additional autoimmune conditions (AICs).
  • People with adult-onset T1D, especially women, should be monitored for other AICs.

Why this matters

  • Additional AICs associated with T1D may have serious health consequences.

Study design

  • Records analyzed for 1212 adults with T1D (age, 19-96 years), including 35.1% with ≥1 AIC.
  • Funding: Washington University Diabetes Research Center; NIH; and other non-industry grants.

Key results

  • Presence of other AICs increased with age, from 19.8% in those ≤29 years to 47.4% for >60 years.
  • Mean current ages for those without vs with additional AICs were 44.3 vs 51.3 years, respectively (P<.0001>
  • aOR for additional AICs for age ≥60 vs ≤29 years was 3.70 (P<.0001>
  • Additional AICs were more common in women vs men (OR, 2.75; P<.0001 and in those with t1d onset vs years>
  • The most common additional AICs were hypothyroidism (22.0%), autoimmune collagen vascular disease (6.5%), hyperthyroidism (5.0%), skin/hair disorders (4.5%), and pernicious anemia (4.5%).

Limitations

  • Single, tertiary referral center study.
  • Lack of standardized screening.
  • No mortality data or genetic testing.