- The KHOALA cohort study finds that chondrocalcinosis (CC) of the knee has no bearing on the 5-year risk for progression of osteoarthritis (OA).
Why this matters
- Contrary to conventional wisdom, CC appears to have no effect on the evolution of OA.
- Population-based, prospective cohort of 656 patients with symptomatic knee and/or hip OA aged 40-75 years without previous total joint (knee or hip) replacement (TJR).
- Primary outcome was time from inclusion or OA diagnosis to total knee replacement (TKR) or TJR.
- Analyses were adjusted for age, sex, BMI, Kellgren-Lawrence (KL) grade by radiography, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores.
- Funding: French Society of Rheumatology; ART-Viggo Association.
- 14.2% of the cohort had knee CC; 13.9% of the cohort underwent TKR during the 5-year course of study.
- Risk for TKR was unaffected by the presence of knee CC (HR, 1.26; 95% CI, 0.74-2.17), as was risk for TJR (HR, 1.14; 95% CI, 0.68-1.92).
- In patients without incident TKR, knee CC failed to affect:
- Worsening of KL grade (OR, 0.9; 95% CI, 0.4-1.7).
- Worsening of WOMAC pain score (OR, 1.1; 95% CI, 0.7-1.4).
- Worsening of WOMAC function score (OR, 0.9; 95% CI, 0.4-2.0).
- Observational design.