Knee chondrocalcinosis not tied to OA progression in KHOALA cohort

  • Latourte A & al.
  • 05/12/2019

  • Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • The KHOALA cohort study finds that chondrocalcinosis (CC) of the knee has no bearing on the 5-year risk for progression of osteoarthritis (OA).

Why this matters

  • Contrary to conventional wisdom, CC appears to have no effect on the evolution of OA.

Study design

  • Population-based, prospective cohort of 656 patients with symptomatic knee and/or hip OA aged 40-75 years without previous total joint (knee or hip) replacement (TJR).
  • Primary outcome was time from inclusion or OA diagnosis to total knee replacement (TKR) or TJR.
  • Analyses were adjusted for age, sex, BMI, Kellgren-Lawrence (KL) grade by radiography, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores.
  • Funding: French Society of Rheumatology; ART-Viggo Association.

Key results

  • 14.2% of the cohort had knee CC; 13.9% of the cohort underwent TKR during the 5-year course of study.
  • Risk for TKR was unaffected by the presence of knee CC (HR, 1.26; 95% CI, 0.74-2.17), as was risk for TJR (HR, 1.14; 95% CI, 0.68-1.92).
  • In patients without incident TKR, knee CC failed to affect:
    • Worsening of KL grade (OR, 0.9; 95% CI, 0.4-1.7).
    • Worsening of WOMAC pain score (OR, 1.1; 95% CI, 0.7-1.4).
    • Worsening of WOMAC function score (OR, 0.9; 95% CI, 0.4-2.0).

Limitations

  • Observational design.