Influenza: benefits of annual vaccination outweigh interference risk

  • Vaccine

  • Liz Scherer
  • Clinical Essentials
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Takeaway

  • Even in the presence of vaccine interference (VI), annual influenza vaccination reduces infection and mortality rates.

Why this matters

  • Despite the potential for VI, repeat, annual influenza vaccination appears to confer better protection compared with vaccination in alternative years.
  • Clinicians should continue to recommend and offer annual influenza vaccination, especially in younger adults (age, 20-64 years) who have low vaccination rates and indirect herd immunity.

Key results

  • The likelihood of influenza increased in relation to increasing VI, indicating that VI may decrease the effectiveness or effect of influenza vaccination.
  • A 10% increase in vaccine coverage was associated with a lower likelihood for influenza disease as long as VI was
  • Annual vaccination is favored as long as residual protection is >55%.
  • Individuals vaccinated in prior seasons are less likely to be infected as long as they are revaccinated in current season and VI level is

Study design

  • Dynamic transmission modeling study analyzing the influence of annual influenza vaccination in the presence of VI.
  • Funding: NIH.

Limitations

  • Some factors affecting vaccine effectiveness (VE) not included.
  • VE, VI data limited to 2 years of vaccination.