- Even in the presence of vaccine interference (VI), annual influenza vaccination reduces infection and mortality rates.
Why this matters
- Despite the potential for VI, repeat, annual influenza vaccination appears to confer better protection compared with vaccination in alternative years.
- Clinicians should continue to recommend and offer annual influenza vaccination, especially in younger adults (age, 20-64 years) who have low vaccination rates and indirect herd immunity.
- The likelihood of influenza increased in relation to increasing VI, indicating that VI may decrease the effectiveness or effect of influenza vaccination.
- A 10% increase in vaccine coverage was associated with a lower likelihood for influenza disease as long as VI was
- Annual vaccination is favored as long as residual protection is >55%.
- Individuals vaccinated in prior seasons are less likely to be infected as long as they are revaccinated in current season and VI level is
- Dynamic transmission modeling study analyzing the influence of annual influenza vaccination in the presence of VI.
- Funding: NIH.
- Some factors affecting vaccine effectiveness (VE) not included.
- VE, VI data limited to 2 years of vaccination.