- Catheter removal within 48 hours of gram-negative bacteremia improves mortality outcomes in patients with cancer who have central-line infections.
Why this matters
- Cancer patients with gram-negative bloodstream infections are at risk for morbidity and mortality.
- Understanding optimal management of central venous catheters (CVCs) in the setting of gram-negative bacteremia will improve survival outcomes.
- Retrospective review of microbiology data for cancer patients age 14 and older reported as having a central venous catheter and gram-negative bloodstream infection.
- Patients were divided into 3 categories:
- CVC infection without mucosal injury (Group 1);
- CVC infection with mucosal injury (Group 2);
- Infection source other than CVC (Group 3).
- The most common organism in patients with CVC and no mucosal injury was Pseudomonas aeruginosa (20%).
- The most common organism in patients with mucosal injury or non-CVC infections was Escherichia coli (66% and 44%).
- Group 1 intervention was the only population with a significant difference in outcomes based on timing of CVC removal.
- There was a decrease in mortality rate at 3 months in group 1 patients who had CVC removal within 48 hours, 3% vs 19%, OR=0.13 (95% CI, 0.03-0.68), P=.016.
- Single-center report.
- Results presented at conference and not peer-reviewed.