- Hydrogen peroxide solution 3% or 6% are both effective treatments for nongenital warts, but 6% was associated with a better overall response, in a randomized controlled trial.
Why this matters
- Available treatment options are not ideal, and hydrogen peroxide is effective, safe, and cheap.
- Hydrogen peroxide (3% or 6%) was associated with a better treatment response than normal saline at 3 and 6 weeks (P=.0001 for all).
- Hydrogen peroxide 6% was associated with a better treatment response than hydrogen peroxide 3% at 3 and 6 weeks (P=.0001 for both).
- Disease duration (P=.001), lesion number (P=.03), and lesion size (P=.03) were negatively associated with treatment response, but clinical type of wart was not (P=.48).
- 1 patient treated with hydrogen peroxide 6% and 1 patient treated with hydrogen peroxide 3% experienced mild hypopigmentation.
- No cured patients experienced recurrence after 3 months.
- 145 patients with nongenital warts were randomly assigned to receive hydrogen peroxide 6% (N=58), hydrogen peroxide 3% (N=58), or normal saline 0.9% (N=29), and were analyzed for treatment response.
- Funding: None disclosed.
- Short follow-up.
- Small patient sample size.