Hydrogen peroxide: a good treatment option for nongenital warts

  • Mahran AM & al.
  • J Cosmet Dermatol
  • 08/06/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Hydrogen peroxide solution 3% or 6% are both effective treatments for nongenital warts, but 6% was associated with a better overall response, in a randomized controlled trial.

Why this matters

  • Available treatment options are not ideal, and hydrogen peroxide is effective, safe, and cheap.

Key results

  • Hydrogen peroxide (3% or 6%) was associated with a better treatment response than normal saline at 3 and 6 weeks (P=.0001 for all).
  • Hydrogen peroxide 6% was associated with a better treatment response than hydrogen peroxide 3% at 3 and 6 weeks (P=.0001 for both).
  • Disease duration (P=.001), lesion number (P=.03), and lesion size (P=.03) were negatively associated with treatment response, but clinical type of wart was not (P=.48).
  • 1 patient treated with hydrogen peroxide 6% and 1 patient treated with hydrogen peroxide 3% experienced mild hypopigmentation.
  • No cured patients experienced recurrence after 3 months.

Study design

  • 145 patients with nongenital warts were randomly assigned to receive hydrogen peroxide 6% (N=58), hydrogen peroxide 3% (N=58), or normal saline 0.9% (N=29), and were analyzed for treatment response.
  • Funding: None disclosed.

Limitations

  • Short follow-up.
  • Small patient sample size.