- Smoking is associated with reduced survival of patients with head and neck squamous cell carcinoma (HNSCC).
Why this matters
- Study lends support to the well-described link between smoking and HNSCC outcomes.
- The overall mortality rate was 54.9% (median follow-up: 81 mo).
- 56.2% of patients were smokers.
- Smokers had reduced median survival time (89 mo vs 208 mo; HR, 1.98; 95% CI, 1.42-2.77).
- 36.5% of smokers had laryngeal cancer, 32.3% had oropharyngeal cancer, and 23.1% had oral cancer.
- Unmarried patients were more likely to use tobacco (OR, 1.77; 95% CI, 1.09-2.87).
- Unmarried patients had reduced survival compared with married patients (HR, 1.87; 95% CI, 1.38-2.53).
- 463 patients with HNSCC were analyzed for survival and associations with smoking and marital status.
- Funding: None disclosed.
- Retrospective study.
- Nonsmokers not stratified into quitters vs never-smokers.