Hidradenitis suppurativa tied to excess mortality risk

  • Reddy S & al.
  • J Am Acad Dermatol
  • 13/06/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Hidradenitis suppurativa (HS) is associated with increased all-cause mortality, according to a population study.

Why this matters

  • Potentially modifiable risk factors include smoking and comorbidities.

Key results

  • Patients with HS had increased mortality risk (OR, 1.14; 95% CI, 1.01-1.28) in adjusted analysis.
    • The excess risk for death attributable to HS was 3.1 deaths per 1000 patients.
  • In subgroup analysis, HS was associated with higher mortality risk in patients aged 40-49 years (OR, 1.64; 95% CI, 1.26-2.12), Caucasians (OR, 1.25; 95% CI, 1.07-1.46), patients with obesity (OR, 1.20; 95% CI, 1.03-1.40), and those with Charlson comorbidity index score ≥5 (OR, 1.31; 95% CI, 1.08-1.59).
  • Risk factors for mortality in HS included age (OR, 1.05; 95% CI, 1.04-1.06 per 1-year increase), male sex (OR, 1.40; 95% CI, 1.09-1.79), ever-smoking status (OR, 1.48; 95% CI, 1.16-1.92), and Charlson comorbidity index score (OR, 1.25; 95% CI, 1.21-1.29 per 1-unit increase).

Study design

  • 13,289 patients with HS and 685,573 control participants from the Explorys platform were included.
  • Funding: AbbVie.

Limitations

  • Retrospective study of large database.