Hidradenitis suppurativa is linked to increased cancer risk

  • Jung JM & al.
  • JAMA Dermatol
  • 27/05/2020

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Hidradenitis suppurativa (HS) is linked to slightly increased overall cancer risk, as well as increased risk for several specific cancers, according to a population-based study.

Why this matters

  • These results suggest that patients with HS may need increased cancer surveillance.

Key results

  • Patients with HS had increased overall cancer risk vs participants with no HS:
    • Adjusted (a)HR, 1.28 (95% CI, 1.15-1.42).
  • Patients with HS had increased risk (aHRs; 95% CIs) for several specific cancers:
    • Hodgkin lymphoma: 5.08 (1.21-21.36).
    • Oral cavity/pharyngeal cancer: 3.10 (1.60-6.02).
    • Central nervous system cancer: 2.40 (1.22-4.70).
    • Nonmelanoma skin cancer: 2.06 (1.12-3.79).
    • Prostate cancer: 2.05 (1.30-3.24). 
    • Colorectal cancer: 1.45 (1.09-1.93).
  • In subgroup analysis, overall cancer risk was significantly increased in males with HS compared with male control participants (1.37; 1.19-1.57), but not in females with HS compared with female control participants (1.15; 0.96-1.37).

Study design

  • 22,468 patients with HS and 179,734 matched control participants from the Korean Health Insurance Review and Assessment Service database were included.
  • Funding: National Research Foundation of Korea, Ministry of Health & Welfare (Republic of Korea).

Limitations

  • Retrospective study of a large database.