Hashimoto’s thyroiditis: 1 in 5 patients complains of rheumatic symptoms

  • Giuffrida G & al.
  • J Endocrinol Invest
  • 12/07/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Patients with Hashimoto’s thyroiditis (HT) without autoimmune comorbidities are at increased risk for nonspecific rheumatic manifestations (RMs), according to a cross-sectional study.

Why this matters

  • Many patients with HT complain of nonspecific RMs such as muscle pain/weakness and arthralgias, but rates and associated factors were poorly understood.

Key results

  • 20% of patients with HT and 6.8% of control subjects complained of ≥1 RM (P<.001>
  • In patients with HT, polyarthralgia, myalgia, primary Raynaud’s phenomenon, carpal tunnel syndrome, and sicca syndrome were the most prevalent RMs.
  • 7% of patients with HT and 0.8% of control subjects had a family history of rheumatic disease (P<.001>
  • In patients with HT, RMs were associated with older age (P<.001 and female sex but not thyroid functional status or vitamin d levels.>

Study design

  • 500 patients with HT and 310 age- and sex-matched control individuals were analyzed for nonspecific RM prevalence and associated factors.
  • Funding: None.

Limitations

  • Observational study design.
  • Lack of follow-up data.