- Compared with nonusers, proton pump inhibitor (PPI) users did not have a significantly elevated risk for dementia regardless of cumulative exposure or duration of use.
Why this matters
- PPIs are commonly prescribed and have been linked to dementia risk in some studies.
- Older adults already have higher dementia incidence.
- Overall, 23.7% of the cohort developed dementia.
- Relative to nonusers, PPI users were not more likely to develop dementia risk (P=.66) or Alzheimer’s disease specifically (P=.77).
- There was no significant elevation of risk with cumulative PPI exposure corresponding to daily use of approximately 1 y (HR, 0.87; 95% CI, 0.65-1.18), 3 y (HR, 0.99; 95% CI, 0.75-1.30), or 5 y (HR, 1.13; 95% CI, 0.82-1.56).
- Additionally, findings were similar regardless of duration of PPI use.
- A population-based prospective cohort study of 3484 dementia-free patients aged 65 y and older (median, 74 y) from an integrated health system.
- Main outcome was incident dementia during mean follow-up of 7.5 y.
- Funding: National Institute on Aging.
- Cumulative dose was assessed for a 10-y period.
- Most patients were of European descent.
- The group with high level of PPI use was small.