- Appendectomy triples the risk of getting Parkinson's disease.
Why this matters
- The potential link between appendectomy and Parkinson’s has been debated for some time. This is the first large-scale epidemiological study examining that question. It should encourage more research in the area of enteric neurons and disease.
- The link between Parkinson’s disease and appendectomy was evaluated via a large commercial database containing more than 68 million health records.
- The study established a washout period of 6 months between the appendectomy and the development of Parkinson’s disease.
- The search found 488,190 patients who underwent appendectomies. Of these, 4470 developed Parkinson’s disease.
- The overall relative risk of developing Parkinson’s disease was 3.19 in patients after appendectomies vs those who did not undergo appendectomy.
- All age groups had an increased risk of developing Parkinson’s disease.
- Caucasians, African Americans, and Asians were at an increased risk of Parkinson’s disease after appendectomies.
- While a washout period was conducted, the time between the appendectomy and the development of Parkinson's disease cannot be determined from the database.