COVID-19: DVT was common among inpatients in Wuhan

  • Zhang L & al.
  • Circulation
  • 18/05/2020

  • Jenny Blair, MD
  • Clinical Essentials
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Takeaway

  • Among inpatients with COVID-19 in Wuhan, China, deep venous thrombosis (DVT) was common, according to results of this single-center study.

Why this matters

Key results

  • 37.1% received low-molecular-weight heparin thromboprophylaxis (similar rates in those with vs without DVT).
  • 74.1% were severely or critically ill.
  • DVT prevalence: 46.1% (66/143 patients). 
  • Among subgroup with Padua score ≥4 who underwent ultrasound >72 hours after admission:
    • Heparin nonprophylaxis vs prophylaxis: 66.0% vs 36.7% (P=.010).
  • DVT vs no DVT:
    • ICU admission: 12 vs 3 (P=.005).
    • Discharges: 32 vs 60 (P<.001>
    • Deaths: 23 vs 9 (P=.001).
  • Risk factors (ORs; 95% CIs) for DVT on multivariate analysis:

Study design

  • Single-center observational study of 159 consecutive patients hospitalized with COVID-19 in Wuhan, China (n=143).
  • All underwent leg ultrasound, echocardiography, except 16 who died or were transferred.
  • Outcomes: DVT prevalence, risk factors, prognosis.
  • Funding: National Natural Science Foundation of China.

Limitations

  • Patients had waited a long time for admission because of crowding.
  • Scant data on thromboprophylaxis. 
  • Pulmonary embolism prevalence not determined.
  • No control group.