Atopic dermatitis linked to heightened risk for colorectal cancer

  • Chou WY & al.
  • Medicine (Baltimore)
  • 01/01/2020

  • Brian Richardson, PhD
  • Clinical Essentials
L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano L'accesso ai contenuti di questo sito è riservato agli operatori del settore sanitario italiano

Takeaway

  • Patients with atopic dermatitis (AD) are at increased risk for colorectal cancer, according to a database analysis from Taiwan.

Why this matters

  • The link between AD and colorectal cancer is controversial, but the association was seen here in a large patient cohort after multivariate adjustment.

Key results

  • AD was associated with increased risk for colorectal cancer in multivariate analysis:
    • HR, 1.26 (95% CI, 1.14-1.40).
  • The association between AD and colorectal cancer was significant (HRs; 95% CIs) in patients aged: 
    • 40-49 years: 1.31 (1.00-1.71).
    • 50-59 years: 1.29 (1.03-1.62).
    • ≥60 years: 1.23 (1.07-1.42).
  • The association between AD and colorectal cancer was significant (HRs; 95% CIs) in:
    • Women: 1.19 (1.02-1.38).
    • Men: 1.35 (1.17-1.55).
  • Frequency of clinical visits for AD was correlated with increased risk (HRs; 95% CIs) for colorectal cancer:
    • 1-2 visits: 1.24 (1.09-1.42). 
    • ≥3 visits: 1.33 (1.15-1.54).
    • P for trend <.0001.>

Study design

  • 46,703 patients with AD and 186,812 unaffected individuals matched for sex, age, and index year from the Taiwan National Health Insurance Research Database were included.
  • Funding: Chi-Mei Hospital.

Limitations

  • Retrospective study of large database.