- Patients with atopic dermatitis (AD) are at increased risk for colorectal cancer, according to a database analysis from Taiwan.
Why this matters
- The link between AD and colorectal cancer is controversial, but the association was seen here in a large patient cohort after multivariate adjustment.
- AD was associated with increased risk for colorectal cancer in multivariate analysis:
- HR, 1.26 (95% CI, 1.14-1.40).
- The association between AD and colorectal cancer was significant (HRs; 95% CIs) in patients aged:
- 40-49 years: 1.31 (1.00-1.71).
- 50-59 years: 1.29 (1.03-1.62).
- ≥60 years: 1.23 (1.07-1.42).
- The association between AD and colorectal cancer was significant (HRs; 95% CIs) in:
- Women: 1.19 (1.02-1.38).
- Men: 1.35 (1.17-1.55).
- Frequency of clinical visits for AD was correlated with increased risk (HRs; 95% CIs) for colorectal cancer:
- 1-2 visits: 1.24 (1.09-1.42).
- ≥3 visits: 1.33 (1.15-1.54).
- P for trend <.0001.>
- 46,703 patients with AD and 186,812 unaffected individuals matched for sex, age, and index year from the Taiwan National Health Insurance Research Database were included.
- Funding: Chi-Mei Hospital.
- Retrospective study of large database.