- Intra-articular atelocollagen injection (CartiZol) is simple, safe, and effective for alleviating knee pain from osteoarthritis, chondromalacia, or other cartilage defects.
Why this matters
- Established osteoarthritis treatments such as corticosteroid and hyaluronic acid (HA) injections relieve pain, but do not repair damaged articular cartilage.
- Patients with osteoarthritis or other cartilaginous disease of the knee joint were randomly assigned to receive intra-articular BioCollagen (n=101) or placebo (saline; n=99) in this double-blinded study.
- Funding: None disclosed.
- The BioCollagen vs placebo group showed significantly better visual analogue scale (VAS) scores at 24 weeks (32.11±25.84 vs 41.14±26.01; P=.0147).
- More patients in the BioCollagen group (vs placebo) reported a greater than 20% (P=.0150) or 40% (P=.0239) improvement in VAS.
- Total adverse events or rate of occurrence of each adverse event showed no significant difference between the 2 groups.
- The Western Ontario and McMaster University Osteoarthritis Index, and the 36-item Short-Form Health showed no significant difference between the 2 groups.
- Long-term effects of pain relief were not observed.
Coauthored with Chitra Ravi, MPharm