Atelocollagen injection alleviates cartilage-related knee pain

  • Lee HS & al.
  • Cartilage
  • 02/08/2019

  • Craig Hicks
  • Clinical Essentials
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Takeaway

  • Intra-articular atelocollagen injection (CartiZol) is simple, safe, and effective for alleviating knee pain from osteoarthritis, chondromalacia, or other cartilage defects.

Why this matters

  • Established osteoarthritis treatments such as corticosteroid and hyaluronic acid (HA) injections relieve pain, but do not repair damaged articular cartilage.

Study design

  • Patients with osteoarthritis or other cartilaginous disease of the knee joint were randomly assigned to receive intra-articular BioCollagen (n=101) or placebo (saline; n=99) in this double-blinded study.
  • Funding: None disclosed.

Key results

  • The BioCollagen vs placebo group showed significantly better visual analogue scale (VAS) scores at 24 weeks (32.11±25.84 vs 41.14±26.01; P=.0147).
  • More patients in the BioCollagen group (vs placebo) reported a greater than 20% (P=.0150) or 40% (P=.0239) improvement in VAS.
  • Total adverse events or rate of occurrence of each adverse event showed no significant difference between the 2 groups.
  • The Western Ontario and McMaster University Osteoarthritis Index, and the 36-item Short-Form Health showed no significant difference between the 2 groups.

Limitations

  •  Long-term effects of pain relief were not observed.

Coauthored with Chitra Ravi, MPharm