ASRM 2019 — Preconception male cannabis use linked to spontaneous abortion


  • Daniel M. Keller, Ph.D
  • Conference Reports
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Takeaway

  • Male cannabis use once or more times per week in the 2 months prior to conception was associated with an approximate doubling of the risk of spontaneous abortion (SAB) in his partner.

Why this matters

  • As cannabis use is common and increasing with decriminalization, clinicians should be aware of this factor in pregnancy loss.

Study design  

  • Prospective study using Pregnancy Study Online preconception cohort.
  • Females 21-45 years; males ≥21 years; attempting to conceive; not using fertility treatment.
  • Male cannabis use in 2 months prior to baseline: none;
  • Follow-up with female partner for 12 months or until pregnancy reported.
  • SAB defined as pregnancy loss at
  • Study funded by National Institutes of Health.

Key results

  • n=1535 couples.
  • Total SABs: 17.5%.
  • Only users ≥1 time/week had elevated SAB: adjusted HR (aHR) vs nonusers: aHR, 2.04 (95% CI, 1.28-3.24).
  • Only users ≥1 time/week had elevated aHR for ≥3 cycles pregnancy attempts at baseline vs nonusers (aHR, 3.8; 95% CI, 1.7-5.0).
  • SAB risk was higher at

Limitations

  • No data on time-varying cannabis use.
  • Cannabis exposure misclassification likely.
  • Possible selection bias.
  • Residual confounding.