- Lifestyle intervention targeting obese women with infertility improved conception chances, even without fertility treatment, especially for women with PCOS.
Why this matters
- Lifestyle interventions that improve the chance of conceiving for women with obesity and infertility could lower costs of fertility treatments, possibly improving effectiveness of assisted reproductive technologies.
- Randomized controlled trial: women 18-40 years old, infertility, and obesity (BMI≥30 kg/m 2 ) or PCOS and overweight (BMI≥27 kg/m 2 ).
- Standard of care control group (CG) or lifestyle program group (LPG) with kinesiologist, nutritionist, and group sessions.
- 108 women completed ≥6 months of study: 51 LPG (PCOS, n=33; non-PCOS, n=18); 57 CG (PCOS, n=35; non-PCOS, n=22).
- Ferring Inc: unrestricted grant for Fit-for-Fertility trial.
- LPG women lost more weight at 6 months vs CG.
- All: −3.19%±4.45% vs −0.77%±3.67% (P=.003), and
- PCOS: −3.66%±4.47% vs −0.93%±4.22% (P=.015).
- At 18 months LPG increased pregnancy rate (60.8%) vs CG (38.6%) (P=.021).
- PCOS women: 57.6% vs 34.3% (P=.05).
- Lifestyle program increased spontaneous pregnancy rates vs CG
- Whole group: 33.3% vs 12.3% (P=.009), and
- PCOS: 27.3% vs 5.7% (P=.016).
- Lifestyle program increased live births for women with PCOS: 54.8% vs CG 31.4% (P=.05).
- Pregnancy rates for women using assisted reproductive technology (ART) trended nonsignificantly higher for all women in LPG.
- Limited power to determine possible effects of lifestyle changes on fertility of women without PCOS.