- A retrospective study identifies clinicopathologic factors associated with amelanotic metastatic melanoma (AMM) compared with pigmented MM (PMM).
Why this matters
- AMM is difficult to diagnose, and risk factors for AMM are poorly understood.
- Patients with AMM were older (OR, 1.03; P<.001 more likely to have history of nonmelanoma skin cancer and red hair less a family mm>50 nevi (OR, 0.38; P<.001 or history of dysplastic nevi compared with patients pmm.>
- Patients with AMM were more likely to have head/neck disease site (OR, 1.87; P=.002), ulceration (OR, 1.69; P<.001 and nodular subtype had greater breslow depth mitotic rate were less likely to have precursor nevi or tumor regression compared with patients>
- AMM was associated with higher misdiagnosis rates (25% vs 12% clinically [P<.001 vs pathologically and reduced survival rates compared with pmm.>
- 933 patients with melanoma, 342 with AMM, and 591 with PMM were analyzed.
- Funding: NCI/NIH.
- Retrospective, single-center study.