Alopecia areata linked to overt autoimmune thyroid diseases

  • Han TY & al.
  • J Dermatol
  • 17/09/2018

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A nationwide, population-based study from Korea suggests that alopecia areata (AA) is associated with increased risk for Graves' disease and Hashimoto thyroiditis.

Why this matters

  • This study supports a link between AA and other autoimmune diseases.

Key results

  • Patients with AA had increased risk for Graves' disease (0.52% vs 0.37%; OR, 1.415 [P<.0001 in multivariate analysis and hashimoto thyroiditis vs or>
  • In subgroup analysis, severe AA (alopecia totalis or alopecia universalis; 5.8% of patients) was also associated with Graves' disease (OR, 1.714; P<.0001 and hashimoto thyroiditis with higher or values than the overall cohort.>
  • AA was not significantly associated with thyroid cancer (OR, 0.998 [P=.8237] in multivariate analysis).

Study design

  • 248,370 patients with AA and 496,740 patients without AA from the Korea National Health Insurance claims database were analyzed for risk for autoimmune thyroid diseases.
  • Funding: National Research Foundation of Korea.

Limitations

  • Some specific demographic and clinical information not available in database.