- A nationwide, population-based study from Korea suggests that alopecia areata (AA) is associated with increased risk for Graves' disease and Hashimoto thyroiditis.
Why this matters
- This study supports a link between AA and other autoimmune diseases.
- Patients with AA had increased risk for Graves' disease (0.52% vs 0.37%; OR, 1.415 [P<.0001 in multivariate analysis and hashimoto thyroiditis vs or>
- In subgroup analysis, severe AA (alopecia totalis or alopecia universalis; 5.8% of patients) was also associated with Graves' disease (OR, 1.714; P<.0001 and hashimoto thyroiditis with higher or values than the overall cohort.>
- AA was not significantly associated with thyroid cancer (OR, 0.998 [P=.8237] in multivariate analysis).
- 248,370 patients with AA and 496,740 patients without AA from the Korea National Health Insurance claims database were analyzed for risk for autoimmune thyroid diseases.
- Funding: National Research Foundation of Korea.
- Some specific demographic and clinical information not available in database.