- Alopecia areata is associated with increased risk for anxiety and depression, according to a systematic review and meta-analysis.
Why this matters
- Studies on the link between alopecia areata and psychiatric disorders have shown conflicting results.
- In quantitative analysis, alopecia areata was associated with anxiety (OR, 2.50; 95% CI, 1.54-4.06) and depression (OR, 2.71; 95% CI, 1.52-4.82).
- In qualitative analysis, 3 studies found no significant association between alopecia areata and anxiety, whereas 6 studies found that patients with alopecia areata had higher anxiety scores.
- In qualitative analysis, 3 studies found no significant association between alopecia areata and depression, whereas 4 studies found that patients with alopecia areata had higher depression scores.
- 17 studies (12 cross-sectional, 5 case-control) were included.
- 8 studies (4 cross-sectional, 4 case-control) including 6010 patients with alopecia areata and 20,961 control participants were included in the quantitative analysis.
- Funding: None.
- Potential publication bias.
- No analysis of alopecia areata severity.