Age at menopause and type of menopause have minor effect on CV risk

  • Heart

  • Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
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Takeaway

  • Age at menopause and type of menopause likely have only a small effect on conventional cardiovascular disease (CVD) intermediates from midlife to age 69 years.

Why this matters

  • Early age at menopause is associated with increased CVD risk.
  • Data from this birth cohort analysis may reassure patients that the effect may be small.

Key results

  • Systolic BP, diastolic BP, BMI, and waist circumference trajectories from age 36 to 69 years were not statistically different by age at menopause onset or type of menopause.
  • Triglycerides, cholesterol measures, and HbA1c trajectories from age 53 to 69 years were not statistically different by either age at onset or type of menopause.

Study design

  • Birth cohort study.
  • Cohort was taken from the UK Medical Research Council (MRC) National Survey of Health and Development.
  • Data were collected longitudinally and prospectively from age 36 to 53 years and from age 36 to 69 years.
  • Conventional CVD intermediates: age at menopause, type of menopause (natural vs hysterectomy), BP, lipids, HbA1c, and BMI were examined.
  • Funding: The UK MRC; individual funding to authors.

Limitations

  • Measures not available for all women.
  • Selection bias possible.