- Preoperative somatostatin analogs (SSAs) are associated with good safety and an improved short-term cure rate in patients with acromegaly receiving transsphenoidal surgery.
Why this matters
- The role of preoperative SSAs in this patient group is controversial.
- Patients who received SSAs had an improved short-term biochemical remission rate compared with those who did not receive SSAs (50.5% vs 35.1%; OR, 2.07; P<.00001 studies patients style="list-style-type:circle;">
- 44.2% vs 15.6% (OR, 4.33; P=.005) for invasive macroadenomas (2 studies, 88 patients).
- 12 studies (5 randomized controlled trials, 2 prospective studies, and 5 retrospective studies) were included in the meta-analysis.
- Of 924 patients with acromegaly undergoing surgery, 445 received preoperative SSAs and 479 did not.
- Funding: None disclosed.
- Heterogeneity between included studies.
- Potential selection bias in some included studies.