Acromegaly associated with increased risk for intracranial meningiomas

  • Engelhardt J & al.
  • Neurosurgery
  • 18/10/2019

  • Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Patients with acromegaly have increased risk of developing intracranial meningiomas, according to an observational study.

Why this matters

  • The association between acromegaly and meningiomas is poorly understood.

Key results

  • Patients with acromegaly had increased risk for intracranial meningiomas compared with patients without acromegaly (7.7% vs 2.2%; OR, 3.45; P=.005).
  • Patients with acromegaly had increased incidence of intracranial meningiomas compared with the general population (standardized incidence ratio, 126; 95% CI, 25-365).

Study design

  • 195 patients with acromegaly and 357 patients with nonsomatotropic pituitary adenoma were assessed by gadolinium-enhanced 3D T1 brain MRI for meningiomas.
  • Funding: None disclosed.

Limitations

  • Cohorts were not matched for sex, although analysis was adjusted for sex ratio.